ColoTectTM
Colorectal Cancer Self-sampling Test

Colorectal Cancer
Self-sampling Test

Why early screening of colorectal cancer matters?

Colorectal cancer (CRC) ranks second among repetitive cancers in Hong Kong. In 2019, there were 5,556 new cases, accounting for 15.8% of the total number of new cancer cases in Hong Kong. There were annually 2,174 deaths, which makes it the second cancer killer in Hong Kong second to lung cancer.[1] Colorectal cancer is one of the most preventable forms of cancer.[2] Research shows, when CRC is detected and diagnosed in its early stages, the 5-year relative survival rate is about 90%. [3]

The second highest mortality in the world.

The third highest incidence worldwide.

Risk of CRC increases drastically after the age of 50 years.

Early screening is a vital step in early detection of CRC.

Colorectal cancer screening options

Colonoscopy Fecal Occult Blood Test ColoTectTM Stool DNA Test
Testing Method At hospital/outpatient clinic, may require sedation Tube with camera inserted in the rectum and advanced through the large intestine to visually inspect the tissue At home collection of stool sample Painless at home collection of stool sample
Sensitivity Invasive diagnostic gold standard Detects hemoglobin in stool but limited sensitivity in early stage or advanced adenomas High sensitivity and high negative predictive value, Detects colorectal adenoma and biomarkers that are continuously shed into the stool
Limitations Low flexibility that needs preparation include diet or staying at hospital Needs diet Eat and drink as usual
Testing time 1-2 days Short Short
Taking laxatives Required Not required Not required

ColoTectTM Approach

ColoTectTM is a non-invasive, highly sensitive test for colorectal cancer (CRC) and precancerous lesions. DNA is extracted from stool sample self-collected at home and used for multiplex methylation specific PCR to detect abnormally methylated CRC marker genes ─ SDC2, ADHFE1, and PPP2R5C.

High Specificity 93%

High Sensitivity 88%

Self-sampling at Home

Non-invasive

Short Test Time

Stratified Process

Three Biomarkers Multiplex Complementary Biomarkers

No Additional preparation required

High Specificity

High Sensitivity

Self-sampling at home

Non-invasive

Short Testing Time

Stratified Process

Three Biomarkers Multiplex Complementary biomarkers

No Additional preparation required

Who should be tested for colorectal cancer? [4]

According to statistics in 2018, colorectal cancer is the most common cancer in Hong Kong. There were 5,634 newly diagnosed colorectal cancer cases, accounting for 16.6% of new cancer cases, or about 1 in 6 new cancer cases.​​​​​​​[1]
  • Individuals aged 50–75 High risk (Biannual)
  • Carriers of material gene of HNPCC (age 25 or above)
  • Carriers of material gene of FAP(age 12 or above)
Most Common Cancers in Hong Kong
Male Female
Median age at time of diagnosis of colorectal cancer
68
59

How to use ColoTectTM at home?

What’s inside of the ColoTectTM Kit ?

1. A sample collection spoon

2. A stool sample tube (with sample preservation buffer inside)

3. A sampling paper

4. A pair of disposable gloves

5. A facial mask

6. A biohazard bag

7. Consent form

8. Instruction manual

ColoTectTM self-sampling testing process

The stool sample collection kit is collected from designated clinics.

Send the stool sample to the designated clinics, and then it will be sent to the laboratory.

Testing is performed in the lab.

Report is delivered to the customer or attending physician.

ColoTectTM Instruction Manual

Prevent Colorectal Cancer, Practice Healthy Living

References:

[1] Hong Kong Cancer Registry. Overview of Hong Kong Cancer Statistics of 2019.

Available at: https://www3.ha.org.hk/cancereg/pdf/ overview/Overview%20of%20HK%20Cancer %20Stat%202019.pdf

[2] World Cancer Research Fund Hong Kong. Colorectal cancer.

Available at: https://www.wcrf-hk.org/hk-en/preventing-cancer/cancer-types/colorectal-cancer

[3] Colorectal Cancer: Early detection, diagnosis, and staging. American Cancer Society; June 2020.

Available at: https://www.cancer.org/cancer/colon-rectal-cancer/detection-diagnosis-staging/detection.html

[4] World Health Organization. Available at https://www.who.int/news-room/fact-sheets/detail/cancer

[5] Recommendation on Colorectal Cancer Screening. Cancer Expert Working Group On Cancer Prevention and Screening; July 2010.

Available at: https://www.chp.gov.hk/files/pdf/ recommendations_on_crc_screening_ 2010.pdf

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